Leptin Shred's formula contains a potent blend of stimulatory ingredients to promote safe, effective and proven weight loss effects. From observing the clinical research provided from trials involving the following three ingredients found within Leptin Shred's formula, we can conclude that the fat-loss effects elicited from the formula are evident.
*African Mango Extract:Research on African mango shows beneficial effects for diabetes and obesity, as well as analgesic, antimicrobial, antioxidant, and GI activity. A clinical source relays an inhibitory effect on the enzyme glycerol-3-phosphate dehydrogenase involved in converting glucose to stored fat (1). An additional reference tested with a 10-week, randomized, double-blind, placebo-controlled study of 102 overweight patients evaluated the effects of African mango seed extract on body weight and associated metabolic parameters. Patients received either 150 mg of African mango seed extract or placebo 30 minutes before lunch and dinner. Patients receiving the extract improved both weight reduction (body weight, body fat, waist circumference) and metabolic parameters (plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin, and leptin levels) (2). There is also evidence available backing this ingredient as effective leptin hormone support, eliciting a decrease in appetite while enhancing thermogenesis (3).
(1). Oben JE, Ngondi JL, Blum K. Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene. Lipids Health Dis . 2008;7:44.
(2). Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CM, Oben JE. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis , significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation. Lipids Health Dis . 2009;8:7.
(3). Oben JE, Ngondi JL, Blum K. Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene. Lipids Health Dis . 2008;7:44.